- 1960s
Jamie Ray as Anne Shirley (1965–1967)
Gracie Finley as Anne Shirley (1968–1974)
Jamie Ray (Anne Shirley) and Barbara Hamilton (Marilla Cuthbert) (1965–1967)
- 1970s
Gracie Finley as Anne Shirley (1968–1974)
Malorie-Ann Spiller as Anne Shirley (1975–1978)
Susan Cuthbert (Anne) and Jim White (Gilbert) (1979–1980)
- 1980s
Thea MacNeil as Anne Shirley (1981–1983)
Leisa Way as Anne Shirley (1987–1990)
Susan Cuthbert (Anne) and Jim White (Gilbert) (1979–1980)
Thea MacNeil (Anne Shirley), Glenda Landry (Diana Barry) and the rest of Charlottetown company. (1981–1983)
Thea MacNeil (Anne) and Andrew MacBean (Gilbert) (1982–1983)
Leisa Way as Anne (1987–1990)
- 1990s
Leisa Way as Anne Shirley (1987–1990, 1993)
Glynis Ranney as Anne Shirley (1991–1992)
Tracy Michailidis as Anne Shirley (1994–1996)
Sharmaine Ryan as Anne Shirley (1998–1999)
Leisa Way as Anne (1987–1990, 1993)
Tracy Michailidis as Anne Shirley (1994–1996)
Tracy Michailidis as Anne Shirley (1994–1996)
Tracy Michailidis (Anne) and Unknown (Mr. Phillips) (1994–1996)
- 2000s
Chilina Kennedy as Anne Shirley (2000–2001)
Jennifer Toulmin as Anne Shirley (2002–2005)
Amy Wallis as Anne Shirley (2006–2009)
- 2010s
- 2020s